Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 7/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21090745 | 0.82 | CTSD (0.50) | CTSDALOX15GAAKDM4EHSD17B10 | |
| SCHEMBL21090792 | 0.80 | CTSD (0.50) | CTSDALOX15GAAKDM4EHSD17B10 | |
| SCHEMBL24254123 | 0.79 | KDM4E (0.58) | CTSDKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL21064290 | 0.71 | CTSD (0.42) | CTSDALOX15GAAKDM4EHSD17B10 | |
| SCHEMBL24827795 | 0.69 | CRBN (0.69) | ALOX15GAA | |
| SCHEMBL15341911 | 0.68 | KDM4E (0.55) | GAAKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL22736790 | 0.67 | TSHR (0.40) | CTSDALOX15GAATSHRPIK3CA | |
| SCHEMBL1664215 | 0.67 | TRPV1 (0.55) | ALOX15GAAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL13244586 | 0.66 | USP5 (0.44) | GAAKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL1666090 | 0.66 | TRPV1 (0.54) | ALOX15GAAKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019112719-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | ANGEX PHARMACEUTICAL, INC. (US) | 2019-06-13 | — | — | WO | disclosed |