Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.67 |
| ▸ | BLM | P54132 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | THPO | P40225 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Halostachine SCHEMBL5076853 | 1.00 | KDM4E (0.68) | KDM4EL3MBTL1HIF1ABLMTDP1 | |
| Halostachine SCHEMBL11007060 | 1.00 | KDM4E (0.68) | KDM4EL3MBTL1HIF1ABLMTDP1 | |
| Halostachine SCHEMBL932123 | 1.00 | KDM4E (0.68) | KDM4EL3MBTL1HIF1ABLMTDP1 | |
| Halostachine SCHEMBL30473042 | 0.98 | KDM4E (0.65) | KDM4EL3MBTL1HIF1ABLMTDP1 | |
| Halostachine SCHEMBL28853304 | 0.92 | HIF1A (0.75) | KDM4EL3MBTL1HIF1ABLMTDP1 | |
| Halostachine SCHEMBL18329334 | 0.90 | KDM4E (0.57) | KDM4EL3MBTL1HIF1ABLMTDP1 | |
| Halostachine SCHEMBL5073538 | 0.90 | KDM4E (0.62) | KDM4EL3MBTL1HIF1ABLMTDP1 | |
| Halostachine SCHEMBL5075636 | 0.90 | KDM4E (0.62) | KDM4EL3MBTL1HIF1ABLMTDP1 | |
| Halostachine SCHEMBL18329341 | 0.87 | KDM4E (0.53) | KDM4EL3MBTL1HIF1ABLMTDP1 | |
| SCHEMBL7066920 | 0.83 | KDM4E (0.63) | KDM4EL3MBTL1HIF1ABLMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 539 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021256679-A1 | PREPARATION METHOD OF 3-[(4S)-8-BROMO-1-METHYL-6-(2-PYRIDINYL)-4H-IMIDAZO[1,2-A][1,4]BENZODIAZEPINE-4-YL]PROPIONIC ACID METHYL ESTER | 하나제약 주식회사 | 2021-12-23 | — | — | WO | claimed |
| US-9526793-B1 | Salts of phenylethylamines and inorganic acids and methods of use thereof | KRAMER RONALD (US) | 2016-12-27 | — | — | US | claimed |
| EP-1363906-B1 | HETEROCYCLIC INHIBITORS OF ERK2 AND USES THEREOF | VERTEX PHARMA (US) | 2015-07-15 | — | — | EP | claimed |
| US-8841347-B2 | Derivatives of aminoalkanols, method of obtaining of aminoalkanols and their use | UNIWERSYTET JAGIELLONSKI (PL) | 2014-09-23 | — | — | US | claimed |
| US-8633251-B2 | Derivatives of aminoalkanols, method of obtaining of aminoalkanols and their use | UNIWERSYTET JAGIELLONSKI (PL) | 2014-01-21 | — | — | US | claimed |
| US-20130289118-A1 | DERIVATIVES OF AMINOALKANOLS, METHOD OF OBTAINING OF AMINOALKANOLS AND THEIR USE | UNIWERSYTET JAGIELLONSKI (PL) | 2013-10-31 | — | — | US | claimed |
| EP-1732896-B1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | AVENTIS PHARMA INC (US) | 2012-12-12 | — | — | EP | claimed |
| US-20120202795-A1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | AVENTIS PHARMACEUTICALS INC. (US) | 2012-08-09 | — | — | US | claimed |
| US-8188101-B2 | Dihydropyridopyrimidines for the treatment of AB-related pathologies | ASTRAZENECA AB (SE) | 2012-05-29 | — | — | US | claimed |
| CN-102272133-A | Modulators of amyloid beta | — | 2011-12-07 | — | — | CN | claimed |
| US-20030092714-A1 | Heterocyclic inhibitors of ERK2 and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2003-05-15 | — | — | US | claimed |
| US-6417195-B1 | LIBRARIES AND COMBINATORIAL CHEMISTRY | LION BIOSCIENCE AG (DE) | 2002-07-09 | — | — | US | claimed |
| EP-1155001-A1 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 2001-11-21 | — | — | EP | claimed |
| WO-2000050406-A1 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | LION BIOSCIENCE AG (DE) | 2000-08-31 | — | — | WO | claimed |
| EP-0863877-A4 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | TORREY PINES INST (US) | 1999-07-21 | — | — | EP | claimed |
| US-5874443-A | BIOSYNTHESIS | TREGA BIOSCIENCES, INC. (US) | 1999-02-23 | — | — | US | claimed |
| EP-0863877-A1 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) | 1998-09-16 | — | — | EP | claimed |
| WO-1997016428-A1 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) | 1997-05-09 | — | — | WO | claimed |
| US-5468486-A | Vaccine containing a protein alkaloid conjugate for the treatment of fescue toxicosis | THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) | 1995-11-21 | — | — | US | claimed |
| US-4085270-A | Sympathicomimetic acyloxy-phenylethanolamine | CHEMISCH-PHARMAZEUTISCHE FABRIK ADOLF KLINGE & CO. (DT) | 1978-04-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202795-A1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | PARP1, PARP2, PARP3 | KDM4E 1262/4885L3MBTL1 2343/4885HIF1A 1443/4885 |
| US-20130289118-A1 | DERIVATIVES OF AMINOALKANOLS, METHOD OF OBTAINING OF AMINOALKANOLS AND THEIR USE | SCN1A, SCN3A, ACHE | KDM4E 2309/4885L3MBTL1 3706/4885HIF1A 2111/4885 |
| US-20030092714-A1 | Heterocyclic inhibitors of ERK2 and uses thereof | MAPK1, MAPK3, MAP2K2 | KDM4E 3549/4885L3MBTL1 1286/4885HIF1A 1925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.