Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2109912 | 0.85 | HDAC1 (0.45) | GAAALDH1A1LMNAPOLBAPLNR | |
| SCHEMBL2108776 | 0.81 | GAA (0.44) | GAAALDH1A1LMNAPOLBAPLNR | |
| SCHEMBL2108802 | 0.78 | CHRNA1 (0.47) | GAAALDH1A1LMNAPOLBAPLNR | |
| SCHEMBL17680521 | 0.77 | SMN1; SMN2 (0.49) | GAAALDH1A1LMNAPOLBAPLNR | |
| SCHEMBL30812042 | 0.76 | CA12 (0.43) | GAAKCNQ3KCNQ2EPHX2 | |
| SCHEMBL646488 | 0.76 | CA12 (0.43) | GAAKCNQ3KCNQ2EPHX2 | |
| SCHEMBL18654067 | 0.76 | GAA (0.45) | GAAALDH1A1LMNAPOLBAPLNR | |
| SCHEMBL24992894 | 0.74 | EPHX2 (0.52) | RAB9AEPHX2MAPT | |
| SCHEMBL23747902 | 0.73 | GAA (0.42) | GAALMNAPOLBAPLNRMEN1 | |
| SCHEMBL392294 | 0.73 | NAMPT (0.51) | CYP17A1NAMPTKCNQ3KCNQ2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158662-B2 | Compounds and compositions as LXR modulators | HAMILTON (BM) | 2012-04-17 | — | — | US | disclosed |
| EP-1713799-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM, LLC (BM) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005077124-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2005-08-25 | — | — | WO | disclosed |