Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24599026 | 0.86 | HDAC1 (0.55) | HDAC1HDAC6NAMPTKDM4EKMT2A | |
| SCHEMBL2109746 | 0.85 | GAA (0.40) | GAAALDH1A1NAMPTMAPKAPK2KMT2A | |
| SCHEMBL16828785 | 0.78 | HDAC1 (0.57) | HDAC1HDAC6ALDH1A1NAMPTKDM4E | |
| SCHEMBL17680521 | 0.78 | SMN1; SMN2 (0.49) | GAAALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL2108776 | 0.77 | GAA (0.44) | GAAALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL9834746 | 0.76 | HDAC1 (0.51) | HDAC1HDAC6GAAKDM4EKMT2A | |
| SCHEMBL22770010 | 0.75 | GAA (0.46) | HDAC1HDAC6GAAALDH1A1NAMPT | |
| SCHEMBL22558261 | 0.75 | RAB9A (0.57) | HDAC1GAAALDH1A1KMT2AMEN1 | |
| SCHEMBL10801436 | 0.74 | L3MBTL1 (0.54) | HDAC1HDAC6GAAALDH1A1KMT2A | |
| SCHEMBL2108802 | 0.73 | CHRNA1 (0.47) | GAAALDH1A1KMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158662-B2 | Compounds and compositions as LXR modulators | HAMILTON (BM) | 2012-04-17 | — | — | US | disclosed |
| EP-1713799-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM, LLC (BM) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005077124-A2 | COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS | IRM LLC (BM) | 2005-08-25 | — | — | WO | disclosed |