Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TARS1 | P26639 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21161054 | 0.85 | SMN1; SMN2 (0.53) | PPARAALDH1A1SMN1; SMN2CYP2C9EGFR | |
| SCHEMBL20047560 | 0.84 | PPARA (0.43) | PPARAALDH1A1SMN1; SMN2CA12CA1 | |
| SCHEMBL21161099 | 0.83 | MMP2 (0.43) | CTDSP1PPARAALDH1A1SMN1; SMN2CA12 | |
| SCHEMBL23502403 | 0.82 | PPARA (0.44) | PPARAALDH1A1SMN1; SMN2TARS1ACACB | |
| SCHEMBL15791260 | 0.82 | KMT2A (0.49) | ALDH1A1SMN1; SMN2CA1CA2CYP2C9 | |
| SCHEMBL20047614 | 0.82 | PPARA (0.48) | PPARAALDH1A1SMN1; SMN2CA12CA1 | |
| SCHEMBL28618106 | 0.80 | LARS1 (0.55) | ALDH1A1SMN1; SMN2CA2EGFRKMT2A | |
| SCHEMBL20047462 | 0.80 | PPARA (0.47) | PPARAALDH1A1ACACBCA12CA1 | |
| SCHEMBL20043408 | 0.76 | PPARA (0.52) | PPARATARS1EGFR | |
| SCHEMBL21161258 | 0.75 | PPARA (0.41) | PPARAALDH1A1SMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118571-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2019-06-20 | — | — | WO | disclosed |