Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.32 |
| ▸ | DNM2 | P50570 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2917889 | 0.89 | KMT2A (0.36) | KMT2ASMN1; SMN2SLC29A1PDE2APDE1B | |
| SCHEMBL6419623 | 0.73 | ACHE (0.47) | KMT2AACHE | |
| SCHEMBL6415887 | 0.73 | ACHE (0.50) | KMT2AACHE | |
| SCHEMBL10005092 | 0.73 | KMT2A (0.54) | KMT2ASMN1; SMN2SLC29A1HDAC1HDAC2 | |
| SCHEMBL373879 | 0.70 | TLR8 (0.36) | TLR8 | |
| SCHEMBL975147 | 0.70 | TLR8 (0.36) | TLR8 | |
| SCHEMBL21098222 | 0.69 | — | — | |
| SCHEMBL31491388 | 0.68 | PDE10A (0.44) | SMN1; SMN2 | |
| SCHEMBL31491313 | 0.68 | NPC1 (0.35) | KMT2ASMN1; SMN2KDM4EL3MBTL1PDE2A | |
| SCHEMBL6415271 | 0.67 | TLR8 (0.58) | KMT2ASLC29A1HDAC1HDAC2TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019115774-A1 | SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIMIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2019-06-20 | — | — | WO | disclosed |