Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.37 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049314 | 0.82 | EIF4A3 (0.36) | EIF4A3 | |
| SCHEMBL12232189 | 0.81 | ALDH1A1 (0.41) | ALDH1A1LMNAKDM4EPOLBCASP6 | |
| SCHEMBL20047702 | 0.78 | EIF4A3 (0.33) | EIF4A3 | |
| SCHEMBL4058945 | 0.77 | ALDH1A1 (0.43) | ALDH1A1LMNAKDM4EPOLBCASP6 | |
| SCHEMBL15296568 | 0.77 | ALDH1A1 (0.51) | ALDH1A1LMNAKDM4EPOLBCASP6 | |
| SCHEMBL24936489 | 0.74 | KDM4E (0.48) | ALDH1A1LMNAKDM4EPOLBCASP6 | |
| SCHEMBL12356977 | 0.74 | ALDH1A1 (0.49) | ALDH1A1LMNAPOLBCYP1A2P2RX7 | |
| SCHEMBL8571925 | 0.73 | ALDH1A1 (0.53) | ALDH1A1LMNAKDM4EPOLBCASP6 | |
| SCHEMBL28910008 | 0.73 | ALDH1A1 (0.44) | ALDH1A1LMNAKDM4EPOLBCASP6 | |
| SCHEMBL12263282 | 0.72 | CCR1 (0.37) | LMNAKDM4ECYP1A2EIF4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118571-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2019-06-20 | — | — | WO | disclosed |