Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21052047 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2GAAPOLBMAPTHTT | |
| SCHEMBL22802061 | 0.88 | SMN1; SMN2 (0.43) | SMN1; SMN2GAAPOLBMAPTHTT | |
| SCHEMBL21098696 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2GAAPOLBMAPTHTT | |
| SCHEMBL21098680 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2GAAPOLBMAPTHTT | |
| SCHEMBL30231974 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2GAAKDM4EPOLBMAPT | |
| SCHEMBL21098749 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2GAAKDM4EPOLBMAPT | |
| SCHEMBL21052174 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2GAAKDM4EPOLBMAPT | |
| SCHEMBL21098752 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2GAAPOLBMAPTHTT | |
| SCHEMBL17732013 | 0.73 | TSHR (0.42) | SMN1; SMN2KDM4EMAPTKMT2AMAOB | |
| SCHEMBL22802055 | 0.72 | MAPT (0.45) | SMN1; SMN2GAAKDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019109188-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-06-13 | — | — | WO | disclosed |