Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 8/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21100226 | 0.87 | PTK2 (0.57) | PTK2EGFRJAK2ALK | |
| SCHEMBL21099819 | 0.84 | IRAK4 (0.53) | PTK2EGFRABCB11ESR1CHRM2 | |
| SCHEMBL19867197 | 0.84 | PTK2 (0.53) | PTK2EGFRABCB11ESR1CHRM2 | |
| SCHEMBL21099556 | 0.80 | IRAK4 (0.56) | PTK2EGFRABCB11ESR1CHRM2 | |
| SCHEMBL21099590 | 0.79 | ALK (0.59) | PTK2EGFRALK | |
| SCHEMBL19867325 | 0.78 | PTK2 (0.53) | PTK2EGFRABCB11ESR1CHRM2 | |
| SCHEMBL21099825 | 0.74 | IRAK4 (0.55) | PTK2EGFRABCB11ESR1CHRM2 | |
| SCHEMBL21100193 | 0.72 | IRAK4 (0.59) | EGFRIRAK4JAK2BRD4ALK | |
| SCHEMBL17893515 | 0.71 | IRAK4 (0.62) | PTK2EGFRABCB11ESR1CHRM2 | |
| SCHEMBL20346177 | 0.71 | EGFR (0.71) | PTK2EGFRABCB11ESR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |