Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL106320 | 0.84 | ALDH1A1 (0.55) | HTTPDPK1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL18340851 | 0.79 | HTT (0.46) | HTTPDPK1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL20297775 | 0.79 | HTT (0.46) | HTTPDPK1ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL21099719 | 0.78 | SMN1; SMN2 (0.72) | HTTPDPK1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL21091402 | 0.78 | PDPK1 (0.49) | HTTPDPK1ALDH1A1SMN1; SMN2NSD1 | |
| SCHEMBL29885344 | 0.78 | PDPK1 (0.49) | HTTPDPK1ALDH1A1SMN1; SMN2NSD1 | |
| SCHEMBL10589885 | 0.78 | SMN1; SMN2 (0.72) | HTTALDH1A1SMN1; SMN2KMT2AHSD17B10 | |
| SCHEMBL288073 | 0.78 | SMN1; SMN2 (0.49) | HTTALDH1A1SMN1; SMN2KMT2AHSD17B10 | |
| Bromide SCHEMBL21839488 | 0.76 | PDPK1 (0.47) | HTTPDPK1ALDH1A1SMN1; SMN2NSD1 | |
| Bromide SCHEMBL29611625 | 0.76 | PDPK1 (0.47) | HTTPDPK1ALDH1A1SMN1; SMN2NSD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230046569-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-02-16 | — | — | US | disclosed |
| US-11324729-B2 | NSD family inhibitors and methods of treatment therewith | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-05-10 | — | — | US | disclosed |
| US-20190183865-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230046569-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | NSD3, NSD2, NSD1 | HTT 2838/4885PDPK1 4206/4885ALDH1A1 3591/4885 |
| US-11324729-B2 | NSD family inhibitors and methods of treatment therewith | NSD3, NSD2, NSD1 | HTT 2838/4885PDPK1 4206/4885ALDH1A1 3591/4885 |
| US-20190183865-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | NSD3, NSD2, NSD1 | HTT 2838/4885PDPK1 4206/4885ALDH1A1 3591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.