Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.60 |
| ▸ | INSR | P06213 | 13/20 | 0.59 |
| ▸ | IGF1R | P08069 | 13/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.57 |
| ▸ | EGFR | P00533 | 5/20 | 0.56 |
| ▸ | STK10 | O94804 | 3/20 | 0.56 |
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | LCK | P06239 | 3/20 | 0.56 |
| ▸ | FYN | P06241 | 3/20 | 0.56 |
| ▸ | FES | P07332 | 3/20 | 0.56 |
| ▸ | YES1 | P07947 | 3/20 | 0.56 |
| ▸ | HCK | P08631 | 3/20 | 0.56 |
| ▸ | ROS1 | P08922 | 3/20 | 0.56 |
| ▸ | FER | P16591 | 3/20 | 0.56 |
| ▸ | LTK | P29376 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | FRK | P42685 | 3/20 | 0.56 |
| ▸ | BTK | Q06187 | 3/20 | 0.56 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.56 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099498 | 0.96 | ALK (0.60) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099421 | 0.93 | ALK (0.63) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099605 | 0.91 | ALK (0.62) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099499 | 0.90 | ALK (0.75) | ALKINSRIGF1REGFRROS1 | |
| SCHEMBL21099502 | 0.89 | ALK (0.59) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL19921194 | 0.88 | ALK (0.59) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099821 | 0.87 | ALK (0.60) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099617 | 0.87 | LRRK2 (0.53) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099428 | 0.86 | ALK (0.60) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL18637132 | 0.86 | ALK (0.81) | ALKINSRIGF1RPTK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |