Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | NSD1 | Q96L73 | 2/20 | 0.64 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12957508 | 0.81 | NSD1 (0.68) | ALDH1A1NSD1PDPK1NSD2NSD3 | |
| SCHEMBL6718517 | 0.81 | ALDH1A1 (1.00) | ALDH1A1NSD1PDPK1NSD2NSD3 | |
| Hydrochloric Acid SCHEMBL1041262 | 0.79 | NSD1 (0.66) | ALDH1A1NSD1PDPK1NSD2NSD3 | |
| SCHEMBL11697325 | 0.78 | ALDH1A1 (0.68) | ALDH1A1NSD1PDPK1NSD2NSD3 | |
| SCHEMBL21091494 | 0.78 | HSD17B10 (0.68) | ALDH1A1NSD1PDPK1NSD2NSD3 | |
| SCHEMBL24616364 | 0.78 | ALDH1A1 (0.68) | ALDH1A1NSD1PDPK1NSD2NSD3 | |
| SCHEMBL21054943 | 0.78 | NSD1 (1.00) | ALDH1A1NSD1PDPK1NSD2NSD3 | |
| SCHEMBL11632384 | 0.78 | ALDH1A1 (0.68) | ALDH1A1NSD1PDPK1NSD2NSD3 | |
| SCHEMBL21091462 | 0.76 | NSD1 (0.62) | ALDH1A1NSD1PDPK1NSD2NSD3 | |
| SCHEMBL12758915 | 0.75 | ALDH1A1 (0.58) | ALDH1A1NSD1PDPK1NSD2NSD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230046569-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-02-16 | — | — | US | disclosed |
| US-11324729-B2 | NSD family inhibitors and methods of treatment therewith | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-05-10 | — | — | US | disclosed |
| US-20190183865-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230046569-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | NSD3, NSD2, NSD1 | ALDH1A1 3591/4885NSD1 3/4885PDPK1 4206/4885 |
| US-11324729-B2 | NSD family inhibitors and methods of treatment therewith | NSD3, NSD2, NSD1 | ALDH1A1 3591/4885NSD1 3/4885PDPK1 4206/4885 |
| US-20190183865-A1 | NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH | NSD3, NSD2, NSD1 | ALDH1A1 3591/4885NSD1 3/4885PDPK1 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.