Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 1.00 |
| ▸ | PIK3CB | P42338 | 12/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 6/20 | 1.00 |
| ▸ | PIK3CG | P48736 | 6/20 | 1.00 |
| ▸ | PRKDC | P78527 | 2/20 | 1.00 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25736875 | 1.00 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL23896256 | 0.92 | PIK3CA (0.85) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL25735869 | 0.92 | PIK3CA (0.85) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL23896257 | 0.92 | PIK3CA (0.85) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL23895633 | 0.90 | PIK3CA (0.81) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL23896129 | 0.89 | PIK3CA (0.80) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL25179016 | 0.89 | PIK3CB (0.80) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL30081718 | 0.89 | PIK3CB (0.80) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL23895845 | 0.89 | PIK3CB (0.80) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC | |
| SCHEMBL23896128 | 0.89 | PIK3CA (0.80) | PIK3CAPIK3CBPIK3CDPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2551270-B1 | PYRAZOLOPYRIMIDINE DERIVATIVES FOR USE AS PI3 KINASE ANTAGONISTS | UNIV CALIFORNIA (US) | 2019-06-12 | — | — | EP | disclosed |