Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.85 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.85 |
| ▸ | PRKDC | P78527 | 2/20 | 0.85 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.85 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.85 |
| ▸ | MTOR | P42345 | 1/20 | 0.59 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23896256 | 1.00 | PIK3CA (0.85) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG | |
| SCHEMBL23896257 | 1.00 | PIK3CA (0.85) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG | |
| SCHEMBL23895633 | 0.92 | PIK3CA (0.81) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG | |
| SCHEMBL21099894 | 0.92 | PIK3CA (1.00) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG | |
| SCHEMBL25736875 | 0.92 | PIK3CA (1.00) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG | |
| SCHEMBL23896128 | 0.91 | PIK3CA (0.80) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG | |
| SCHEMBL23896129 | 0.91 | PIK3CA (0.80) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG | |
| SCHEMBL23895795 | 0.90 | PIK3CA (0.79) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG | |
| SCHEMBL30081835 | 0.90 | PIK3CA (0.79) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG | |
| SCHEMBL23887081 | 0.90 | PIK3CA (0.79) | PIK3CAPIK3CBPRKDCPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | THE BROAD INSTITUTE, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | COASY, JMJD7, PTMS | PIK3CA 3409/4885PIK3CB 2319/4885PRKDC 796/4885 |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | ERBB2, ACP1, TK1 | PIK3CA 377/4885PIK3CB 256/4885PRKDC 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.