Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22542536 | 0.84 | GAA (0.65) | GAAHTTNPC1RAB9AKMT2A | |
| SCHEMBL6245092 | 0.82 | GAA (1.00) | GAANPC1RAB9AKMT2AHSD17B10 | |
| SCHEMBL626827 | 0.81 | GAA (0.76) | GAAHTTNPC1RAB9AKMT2A | |
| SCHEMBL30071250 | 0.81 | GAA (0.76) | GAAHTTNPC1RAB9AKMT2A | |
| SCHEMBL9689348 | 0.79 | GAA (0.79) | GAAHTTNPC1RAB9AKMT2A | |
| Bromide SCHEMBL11500766 | 0.79 | GAA (0.73) | GAAHTTNPC1RAB9AKMT2A | |
| SCHEMBL4491035 | 0.79 | GAA (0.79) | GAANPC1RAB9AKMT2AHSD17B10 | |
| SCHEMBL7006640 | 0.79 | GAA (0.79) | GAANPC1RAB9AKMT2AHSD17B10 | |
| SCHEMBL2562391 | 0.78 | GAA (0.71) | GAAHTTNPC1RAB9AHSD17B10 | |
| SCHEMBL20220978 | 0.78 | GAA (0.71) | GAANPC1RAB9AKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118313-A1 | IMIDAZO [1,2-C] QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME CORP. (US) | 2019-06-20 | — | — | WO | disclosed |