Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | PTAFR | P25105 | 6/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21100312 | 0.84 | KDM4E (0.62) | KDM4EPTAFRALDH1A1CYP19A1NAMPT | |
| SCHEMBL21045190 | 0.81 | KDM4E (0.58) | KDM4EPTAFRPSEN1PSEN2APH1B | |
| SCHEMBL21045212 | 0.81 | KDM4E (0.57) | KDM4EPTAFRPSEN1PSEN2APH1B | |
| SCHEMBL29411414 | 0.81 | KDM4E (0.57) | KDM4EPTAFRPSEN1PSEN2APH1B | |
| SCHEMBL21045518 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1TDP1NAMPT | |
| SCHEMBL21045557 | 0.81 | KDM4E (0.52) | KDM4EPTAFRPSEN1PSEN2APH1B | |
| SCHEMBL21100619 | 0.80 | SMN1; SMN2 (0.48) | PTAFRPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21045426 | 0.80 | KDM4E (0.51) | KDM4EPTAFRPSEN1PSEN2APH1B | |
| SCHEMBL21045238 | 0.80 | KDM4E (0.51) | KDM4EPTAFRPSEN1PSEN2APH1B | |
| SCHEMBL29411466 | 0.80 | KDM4E (0.51) | KDM4EPTAFRPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019113242-A1 | TUBULIN INHIBITORS | Lin BioScience, LLC (US) | 2019-06-13 | — | — | WO | disclosed |