Tibrofan

Tibrofan

SCHEMBL2110124

O=C(Nc1ccc(Br)cc1)c1cc(Br)c(Br)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 9/20 1.00
KMT2A Q03164 9/20 1.00
MAPT P10636 7/20 0.61
ALDH1A1 P00352 3/20 0.61
HTT P42858 3/20 0.61
LMNA P02545 2/20 0.61
KDM4E B2RXH2 1/20 0.61
POLB P06746 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
TP53 P04637 3/20 0.51
NPC1 O15118 3/20 0.50
RAB9A P51151 3/20 0.50
EGFR P00533 1/20 0.50
ERBB2 P04626 1/20 0.50
CYP1A2 P05177 1/20 0.50
LCK P06239 1/20 0.50
CYP2C9 P11712 1/20 0.50
PTGS1 P23219 1/20 0.50
MAPK1 P28482 1/20 0.50
MAPK14 Q16539 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9423236 0.87 KMT2A (0.77) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL24669908 0.84 MEN1 (0.72) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL9422578 0.81 KMT2A (0.68) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL17433469 0.76 MEN1 (0.61) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL24669279 0.76 KMT2A (0.61) MEN1KMT2AMAPTALDH1A1KDM4E
SCHEMBL8376338 0.74 KMT2A (0.59) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL9422985 0.74 KMT2A (0.62) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL24669180 0.73 KMT2A (0.58) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL9423259 0.72 MEN1 (0.56) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL9422914 0.71 CISD2 (0.56) MEN1KMT2AMAPTALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-5369124-A Fungicides BAYER AKTIENGESELLSCHAFT (DE) 1994-11-29 US claimed
JP-6220043-A None JP disclosed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
US-20140154313-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2014-06-05 US disclosed
EP-2717860-A1 CONTROLLED ABSORPTION WATER-SOLUBLE PHARMACEUTICALLY ACTIVE ORGANIC COMPOUND FORMULATION FOR ONCE-DAILY ADMINISTRATION STI Pharma, LLC (US) 2014-04-16 EP disclosed
CN-1035254-C Substituted thiophenecarboxamides BAYER AG (DE) 1997-06-25 CN disclosed
US-5369124-A Fungicides BAYER AKTIENGESELLSCHAFT (DE) 1994-11-29 US disclosed
US-5369124-A Fungicides BAYER AKTIENGESELLSCHAFT (DE) 1994-11-29 US disclosed
JP-H06220043-A SUBSTITUTED THIOPHENECARBOXAMIDE BAYER AG 1994-08-09 JP disclosed
CN-1090280-A The thiophenecarboxamides that replaces BAYER AG (DE) 1994-08-03 CN disclosed
EP-0590458-A1 Substituted thiophene carboxylic acid amides BAYER AG (DE) 1994-04-06 EP disclosed
EP-0590458-A1 Substituted thiophene carboxylic acid amides BAYER AG (DE) 1994-04-06 EP disclosed