Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 9/20 | 0.71 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | FAP | Q12884 | 2/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 2/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | PLD2 | O14939 | 1/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16267642 | 0.83 | PREP (1.00) | PREPFAP | |
| SCHEMBL15138952 | 0.83 | PREP (1.00) | PREPFAP | |
| SCHEMBL22811035 | 0.82 | PREP (0.69) | PREPCHRNB2CHRNA7CHRNA4FAP | |
| SCHEMBL771034 | 0.75 | PREP (0.59) | PREPCHRNB2CHRNA7CHRNA4KDM2B | |
| SCHEMBL5309154 | 0.73 | MGAM (0.62) | PREPHPGDS | |
| SCHEMBL13113540 | 0.72 | MGAM (0.56) | PREPHPGDS | |
| SCHEMBL18848580 | 0.71 | PREP (0.55) | PREPHPGDS | |
| SCHEMBL28071107 | 0.71 | PLD1 (0.62) | PLD2PLD1 | |
| SCHEMBL2639342 | 0.69 | PPARD (0.57) | PREPPLD2PLD1HPGDS | |
| SCHEMBL31458376 | 0.69 | TAOK1 (0.79) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2804859-B1 | NOVEL FAP INHIBITORS | UNIV ANTWERPEN (BE) | 2019-06-12 | — | — | EP | disclosed |