Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.36 |
| ▸ | CDK1 | P06493 | 5/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | AHCY | P23526 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21101808 | 0.93 | CDK1 (0.34) | CDK2CDK1CCNE1CCNB1PRKACA | |
| SCHEMBL21101589 | 0.92 | CDK2 (0.38) | CDK2CDK1CCNE1CCNB1PRKACA | |
| SCHEMBL21101442 | 0.87 | CDK2 (0.47) | CDK2CDK1CCNE1CCNB1PRKACA | |
| SCHEMBL21101443 | 0.86 | CDK1 (0.52) | CDK2CDK1CCNE1CCNB1PRKACA | |
| SCHEMBL21136339 | 0.85 | CDK2 (0.40) | CDK2CDK1CCNE1CCNB1PRKACA | |
| SCHEMBL23790865 | 0.82 | CDK1 (0.45) | CDK2CDK1CCNE1CCNB1PRKACA | |
| SCHEMBL21101586 | 0.82 | CDK1 (0.45) | CDK2CDK1CCNE1CCNB1PRKACA | |
| SCHEMBL21102195 | 0.81 | CDK1 (0.33) | CDK2CDK1CCNE1CCNB1PRKACA | |
| SCHEMBL24939854 | 0.81 | CDK1 (0.33) | CDK2CDK1CCNE1CCNB1PRKACA | |
| SCHEMBL19644727 | 0.81 | CDK1 (0.33) | CDK2CDK1CCNE1CCNB1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10815266-B2 | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment | Atea Pharmaceuticals, Inc. (US) | 2020-10-27 | — | — | US | disclosed |
| US-20190177356-A1 | BETA-D-2'-DEOXY-2'-ALPHA-FLUORO-2'-BETA-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT | Atea Pharmaceuticals, Inc. (US) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10815266-B2 | β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment | NSUN2, PNP, NUDT1 | CDK2 1995/4885CDK1 3678/4885CCNE1 4041/4885 |
| US-20190177356-A1 | BETA-D-2'-DEOXY-2'-ALPHA-FLUORO-2'-BETA-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT | NSUN2, NUDT1, DCTD | CDK2 1661/4885CDK1 3744/4885CCNE1 3354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.