Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | PREP | P48147 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1022056 | 0.79 | ACE (0.40) | ACECNR2DPP4DPP8DPP7 | |
| SCHEMBL28789465 | 0.79 | ACE (0.40) | ACECNR2DPP4DPP8DPP7 | |
| SCHEMBL6002706 | 0.79 | ACE (0.40) | ACECNR2DPP4DPP8DPP7 | |
| SCHEMBL7771045 | 0.76 | TSHR (0.41) | ACECNR2DPP4DPP8DPP7 | |
| SCHEMBL30811430 | 0.74 | CNR2 (0.38) | ACECNR2DPP4DPP8PREP | |
| SCHEMBL31472471 | 0.74 | CNR2 (0.38) | ACECNR2DPP4DPP8PREP | |
| SCHEMBL7769272 | 0.74 | GAA (0.42) | ACECNR2DPP4PREP | |
| SCHEMBL1021746 | 0.73 | CNR2 (0.37) | ACECNR2ALDH1A1PREP | |
| SCHEMBL17282590 | 0.73 | ACE (0.43) | ACECNR2DPP4DPP8DPP7 | |
| SCHEMBL1021093 | 0.73 | ATM (0.44) | ACECNR2HSD17B10PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |