Sugi Predict

Sugi Predict / Compounds / SCHEMBL21115006

SCHEMBL21115006

SCHEMBL21115006

CNc1c(C#N)c(Br)nn1[C@H]1CCN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 7/20 0.39
▸ BTK Q06187 1/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ USP30 Q70CQ3 1/20 0.37
▸ PIK3CD O00329 1/20 0.37
▸ PIK3R2 O00459 1/20 0.37
▸ PIK3CA P42336 1/20 0.37
▸ PIK3CB P42338 1/20 0.37
▸ PIK3CG P48736 1/20 0.37
▸ PIK3R5 Q8WYR1 1/20 0.37
▸ PIK3R3 Q92569 1/20 0.37
▸ JAK2 O60674 6/20 0.36
▸ JAK1 P23458 6/20 0.36
▸ NSD2 O96028 1/20 0.35
▸ KCNH2 Q12809 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21115007 1.00 GPR119 (0.39) GPR119BTKMEN1ALDH1A1MAPT
SCHEMBL30461489 0.88 EPHX1 (0.41) GPR119BTKMEN1ALDH1A1MAPT
SCHEMBL28995639 0.88 BTK (0.40) GPR119BTKMEN1ALDH1A1MAPT
SCHEMBL28995815 0.88 IDO1 (0.42) GPR119BTKMEN1ALDH1A1MAPT
SCHEMBL28995746 0.87 GPR119 (0.41) GPR119BTKMEN1ALDH1A1MAPT
SCHEMBL26760030 0.87 GPR119 (0.41) GPR119BTKMEN1ALDH1A1MAPT
SCHEMBL28995873 0.86 FGFR1 (0.40) GPR119BTKMEN1ALDH1A1MAPT
SCHEMBL21114946 0.85 GPR119 (0.40) GPR119BTKMEN1ALDH1A1MAPT
SCHEMBL28703609 0.85 GPR119 (0.40) GPR119BTKMEN1ALDH1A1MAPT
SCHEMBL21114947 0.85 GPR119 (0.40) GPR119BTKMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250333399-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES KHORA SPV 1 LLC (US) 2025-10-30 — — US disclosed
US-12331039-B2 Inhibitors of fibroblast growth factor receptor kinases KHORA SPV 1, LLC (US) 2025-06-17 — — US disclosed
US-20230348417-A1 PROCESS FOR PREPARING (S)-1-(1-ACRYLOYLPYRROLIDIN-3-YL)-3-((3,5-DIMETHOXYPHENYL) ETHYNYL)-5-(METHYLAMINO)-1H-PYRAZOLE-4-CARBOXAMIDE BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) 2023-11-02 — — US disclosed
US-20230348417-A1 PROCESS FOR PREPARING (S)-1-(1-ACRYLOYLPYRROLIDIN-3-YL)-3-((3,5-DIMETHOXYPHENYL) ETHYNYL)-5-(METHYLAMINO)-1H-PYRAZOLE-4-CARBOXAMIDE BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) 2023-11-02 — — US disclosed
CN-116685582-A Preparation process of (S) -1- (1-acryloylpyrrolidine-3-yl) -3- ((3, 5-dimethoxyphenyl) ethynyl) -5- (methylamino) -1H-pyrazole-4-carboxamide 北京诺诚健华医药科技有限公司 2023-09-01 — — CN disclosed
CN-116057045-A Fibroblast growth factor receptor kinase inhibitors 金耐特生物制药公司 2023-05-02 — — CN disclosed
EP-4161656-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES Kinnate Biopharma Inc. (US) 2023-04-12 — — EP disclosed
US-20230078839-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES KHORA SPV 1, LLC 2023-03-16 — — US disclosed
US-11572353-B2 Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) 2023-02-07 — — US disclosed
EP-3517535-B1 ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF BEIJING INNOCARE PHARMA TECH CO LTD (CN) 2022-06-29 — — EP disclosed
CN-109843873-B Alkyne heterocyclic compound, preparation method and application thereof in medicine and pharmacology 北京诺诚健华医药科技有限公司 2022-06-17 — — CN disclosed
US-11345681-B1 Inhibitors of fibroblast growth factor receptor kinases KINNATE BIOPHARMA INC. (US) 2022-05-31 — — US disclosed
US-20210332027-A1 ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) 2021-10-28 — — US disclosed
US-11059805-B2 Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) 2021-07-13 — — US disclosed
US-20200339541-A1 ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) 2020-10-29 — — US disclosed
US-10710981-B2 Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) 2020-07-14 — — US disclosed
EP-3517535-A1 ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF Beijing InnoCare Pharma Tech Co., Ltd. (CN) 2019-07-31 — — EP disclosed
US-20190210997-A1 ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) 2019-07-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200339541-A1 ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF FGFR1, FGFR4, FGFR3 GPR119 391/4885BTK 107/4885MEN1 467/4885
US-20190210997-A1 ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF FGFR1, FGFR4, FGFR3 GPR119 391/4885BTK 107/4885MEN1 467/4885
US-11572353-B2 Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof FGFR1, FGFR4, FGFR3 GPR119 391/4885BTK 107/4885MEN1 467/4885
US-10710981-B2 Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof FGFR1, FGFR4, FGFR3 GPR119 391/4885BTK 107/4885MEN1 467/4885
US-12331039-B2 Inhibitors of fibroblast growth factor receptor kinases FGFR1, FGFR2, FGFR3 GPR119 862/4885BTK 187/4885MEN1 2735/4885
US-20210332027-A1 ALKYNYL-SUBSTITUTED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF FGFR1, FGFR4, FGFR3 GPR119 391/4885BTK 107/4885MEN1 467/4885
US-20250333399-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES FGFR1, FGFR2, FGFR3 GPR119 862/4885BTK 187/4885MEN1 2735/4885
US-20230348417-A1 PROCESS FOR PREPARING (S)-1-(1-ACRYLOYLPYRROLIDIN-3-YL)-3-((3,5-DIMETHOXYPHENYL) ETHYNYL)-5-(METHYLAMINO)-1H-PYRAZOLE-4-CARBOXAMIDE CYP2E1, CYP1A1, SKP1 GPR119 3485/4885BTK 3187/4885MEN1 161/4885
US-11059805-B2 Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof FGFR1, FGFR4, FGFR3 GPR119 391/4885BTK 107/4885MEN1 467/4885
US-11345681-B1 Inhibitors of fibroblast growth factor receptor kinases FGFR1, FGFR2, FGFR3 GPR119 862/4885BTK 187/4885MEN1 2735/4885
US-20230078839-A1 INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES FGFR1, FGFR2, FGFR3 GPR119 862/4885BTK 187/4885MEN1 2735/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.