Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980609 | 0.93 | HPGD (0.41) | HPGDMAPTTSHRMAPK1NPSR1 | |
| SCHEMBL19980618 | 0.85 | HPGD (0.34) | HPGDMAPTTSHRMAPK1NPSR1 | |
| SCHEMBL19980615 | 0.82 | HPGD (0.36) | HPGDMAPTTSHRMAPK1NPSR1 | |
| SCHEMBL21111986 | 0.80 | MAPT (0.34) | HPGDMAPTTSHRMAPK1NPSR1 | |
| SCHEMBL19980471 | 0.79 | L3MBTL1 (0.30) | TSHR | |
| SCHEMBL21111994 | 0.79 | PDE6D (0.32) | TSHR | |
| SCHEMBL23873806 | 0.77 | MEN1 (0.47) | HPGDMAPTMAPK1NPSR1 | |
| SCHEMBL23873756 | 0.77 | MEN1 (0.47) | HPGDMAPTMAPK1NPSR1 | |
| SCHEMBL17887202 | 0.76 | MEN1 (0.46) | HPGDMAPTMAPK1NPSR1 | |
| SCHEMBL17887204 | 0.76 | MEN1 (0.46) | HPGDMAPTMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512841-B1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2023-04-26 | — | — | EP | disclosed |
| US-11447464-B2 | Compounds with spirobifluorene-structures | MERCK PATENT GMBH (DE) | 2022-09-20 | — | — | US | disclosed |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447464-B2 | Compounds with spirobifluorene-structures | SLCO1B3, SLCO4C1, SLCO1B1 | HPGD 1211/4885MAPT 1792/4885TSHR 3504/4885 |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | SLCO1B3, SLCO4C1, SLCO1B1 | HPGD 1211/4885MAPT 1792/4885TSHR 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.