SCHEMBL21115754

SCHEMBL21115754

C=C(C)C(=O)OCCCc1cc(-c2ccc(-c3ccc(-c4ccc(C)cc4)cc3F)cc2CC)cc(CCCOC(=O)C(=C)C)c1OCCC(CO)(CO)CCCC

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 3/20 0.32
S1PR3 Q99500 2/20 0.32
PPARD Q03181 1/20 0.31
IDO1 P14902 2/20 0.31
TSHR P16473 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20288237 0.95 TSHR (0.33) IDO1TSHR
SCHEMBL21097804 0.95 TSHR (0.33) IDO1TSHR
SCHEMBL21096714 0.94 PPARD (0.33) S1PR1S1PR3PPARDIDO1TSHR
SCHEMBL21098568 0.93 TSHR (0.33) IDO1TSHR
SCHEMBL18645796 0.93 RARB (0.39) S1PR1S1PR3PPARDIDO1TSHR
SCHEMBL21115764 0.91 S1PR1 (0.33) S1PR1S1PR3PPARDIDO1TSHR
SCHEMBL21097851 0.91 IDO1 (0.33) IDO1TSHR
SCHEMBL21097803 0.91 IDO1 (0.33) IDO1TSHR
SCHEMBL21232267 0.90 S1PR1 (0.34) S1PR1S1PR3
SCHEMBL22068223 0.90 RARB (0.37) S1PR1S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3502210-B1 LIQUID-CRYSTAL MEDIUM MERCK PATENT GMBH (DE) 2020-09-09 EP disclosed
EP-3502210-A1 LIQUID-CRYSTAL MEDIUM Merck Patent GmbH (DE) 2019-06-26 EP disclosed