Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675348 | 0.77 | CDK5 (0.50) | L3MBTL1TDP1CCNA2CDK2CCNA1 | |
| SCHEMBL2096015 | 0.77 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1TDP1LMNAMAPT | |
| SCHEMBL21115997 | 0.76 | ALDH1A1 (0.67) | ALDH1A1L3MBTL1TDP1CCNA2CDK2 | |
| SCHEMBL2096012 | 0.73 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1TDP1CCNA2CDK2 | |
| SCHEMBL13996109 | 0.72 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1TDP1CCNA2CDK2 | |
| SCHEMBL18015824 | 0.72 | ALDH1A1 (0.73) | ALDH1A1L3MBTL1TDP1CCNA2CDK2 | |
| SCHEMBL1916379 | 0.71 | NPC1 (0.58) | ALDH1A1L3MBTL1TDP1LMNAMAPT | |
| SCHEMBL2431805 | 0.70 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1TDP1CCNA2CDK2 | |
| SCHEMBL759746 | 0.70 | KDM4E (0.58) | ALDH1A1L3MBTL1TDP1CCNA2CDK2 | |
| SCHEMBL28522857 | 0.70 | CYP19A1 (0.59) | ALDH1A1L3MBTL1TDP1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-B1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER (US) | 2019-06-26 | — | — | EP | disclosed |