Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.44 |
| ▸ | RELA | Q04206 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10890003 | 0.81 | TSHR (0.49) | TSHRRAB9ASMN1; SMN2NPC1GRM5 | |
| SCHEMBL11924524 | 0.76 | TSHR (0.63) | TSHRRAB9ASMN1; SMN2NPC1GAA | |
| SCHEMBL10893635 | 0.75 | APOBEC3A (0.53) | TSHRRAB9ASMN1; SMN2NPC1GRM5 | |
| SCHEMBL19990184 | 0.75 | TSHR (0.57) | TSHRRAB9ASMN1; SMN2NPC1GRM5 | |
| Hydrochloric Acid SCHEMBL10893751 | 0.73 | APOBEC3A (0.52) | TSHRRAB9ASMN1; SMN2NPC1GRM5 | |
| SCHEMBL12890455 | 0.72 | TSHR (0.54) | TSHRRAB9ASMN1; SMN2NPC1GRM5 | |
| SCHEMBL659214 | 0.71 | TSHR (0.71) | TSHRRAB9ASMN1; SMN2NPC1GAA | |
| SCHEMBL7955024 | 0.71 | TSHR (0.67) | TSHRRAB9ASMN1; SMN2NPC1GAA | |
| SCHEMBL10996172 | 0.71 | TSHR (0.43) | TSHRRAB9ASMN1; SMN2NPC1GRM5 | |
| SCHEMBL15332856 | 0.71 | PDK1 (0.48) | TSHRRAB9ASMN1; SMN2NPC1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |