Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20333683 | 0.84 | CARM1 (0.45) | SMN1; SMN2KDM1AMEN1KMT2AALDH1A1 | |
| SCHEMBL2994842 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM1APAOXCYP2D6MEN1 | |
| SCHEMBL23183525 | 0.83 | ACE2 (0.42) | SMN1; SMN2KDM1AMEN1KMT2AALDH1A1 | |
| SCHEMBL21120600 | 0.83 | CARM1 (0.44) | KDM1AALDH1A1CA12CA1CA2 | |
| SCHEMBL12838847 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP2D6MEN1KMT2AALDH1A1 | |
| SCHEMBL20332563 | 0.81 | MEN1 (0.45) | SMN1; SMN2CYP2D6MEN1KMT2AALDH1A1 | |
| SCHEMBL4401738 | 0.80 | CA12 (0.53) | SMN1; SMN2KDM1APAOXALDH1A1CA12 | |
| SCHEMBL14805807 | 0.79 | PAOX (0.49) | SMN1; SMN2KDM1APAOXCYP2D6MEN1 | |
| SCHEMBL18410958 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2CYP2D6MEN1KMT2AALDH1A1 | |
| SCHEMBL13520192 | 0.78 | TSHR (0.49) | SMN1; SMN2KDM1APAOXCYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399303-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | UNIV YALE (US) | 2023-12-14 | — | — | US | disclosed |
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2019-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | MIF, MMP12, CSF1R | SMN1; SMN2 4652/4885KDM1A 3944/4885PAOX 1249/4885 |
| US-20230399303-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | MIF, MMP12, METAP1 | SMN1; SMN2 3388/4885KDM1A 1102/4885PAOX 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.