SCHEMBL21119115

SCHEMBL21119115

C=C1CCC(=C)C(=O)NC(=O)N1

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.38
OGT O15294 1/20 0.38
USP2 O75604 1/20 0.38
MAPT P10636 1/20 0.38
RECQL P46063 1/20 0.38
BLM P54132 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10613910 0.84 CRBN (0.37) KDM4EOGTUSP2MAPTRECQL
SCHEMBL4389515 0.72
SCHEMBL1688098 0.66
SCHEMBL7883459 0.65
SCHEMBL11937037 0.64 KDM4E (0.53) KDM4EOGTUSP2MAPTRECQL
SCHEMBL123424 0.62
SCHEMBL631517 0.62
SCHEMBL13570172 0.62 CRBN (0.48) MAPTBLM
SCHEMBL4454371 0.62
SCHEMBL8272750 0.58

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2279291-B1 COFERONS AND METHODS OF MAKING AND USING THEM UNIV CORNELL (US) 2019-07-03 EP disclosed