Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | ITK | Q08881 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.31 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.30 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211198 | 1.00 | MET (0.36) | METEGFRITKAURKBGSK3B | |
| SCHEMBL210544 | 0.96 | ITK (0.37) | METEGFRITKGSK3BDYRK1A | |
| SCHEMBL210474 | 0.92 | MET (0.36) | METEGFRITKAURKBGSK3B | |
| SCHEMBL210473 | 0.92 | MET (0.36) | METEGFRITKAURKBGSK3B | |
| SCHEMBL210475 | 0.92 | MET (0.36) | METEGFRITKAURKBGSK3B | |
| SCHEMBL209938 | 0.91 | GSK3B (0.33) | METEGFRITKGSK3BDYRK1A | |
| SCHEMBL211555 | 0.90 | ABL1 (0.31) | ABL1 | |
| SCHEMBL213551 | 0.90 | ITK (0.34) | METEGFRITKGSK3BDYRK1A | |
| SCHEMBL2723148 | 0.90 | ABL1 (0.37) | EGFRCDK9ABL1CCNT1 | |
| SCHEMBL213607 | 0.90 | CARM1 (0.35) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |