⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130080 | 0.89 | — | — | |
| SCHEMBL21129809 | 0.85 | — | — | |
| SCHEMBL21130158 | 0.80 | PRMT5 (0.39) | — | |
| SCHEMBL21130015 | 0.78 | — | — | |
| SCHEMBL23966904 | 0.73 | GRM7 (0.34) | — | |
| SCHEMBL30180778 | 0.73 | GRM7 (0.34) | — | |
| SCHEMBL23476391 | 0.73 | PRMT5 (0.31) | — | |
| SCHEMBL21129808 | 0.70 | PRMT5 (0.37) | — | |
| SCHEMBL21130002 | 0.70 | PRMT5 (0.39) | — | |
| SCHEMBL21130294 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2019116302-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2019-06-20 | — | — | WO | disclosed |