⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130078 | 0.88 | — | — | |
| SCHEMBL21130291 | 0.81 | MKNK2 (0.33) | — | |
| SCHEMBL21130006 | 0.78 | — | — | |
| SCHEMBL21130158 | 0.75 | PRMT5 (0.39) | — | |
| SCHEMBL27033337 | 0.73 | AURKA (0.41) | — | |
| SCHEMBL4202568 | 0.71 | CDK4 (0.47) | — | |
| SCHEMBL25209675 | 0.70 | GRM2 (0.41) | — | |
| SCHEMBL25209677 | 0.70 | GRM2 (0.41) | — | |
| SCHEMBL31095262 | 0.70 | GRM2 (0.41) | — | |
| SCHEMBL21130012 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980417-B1 | PRMT5 INHIBITORS | LUPIN LTD (IN) | 2023-09-27 | — | — | EP | disclosed |
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2020250123-A1 | PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2020-12-17 | — | — | WO | disclosed |
| WO-2019116302-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2019-06-20 | — | — | WO | disclosed |