Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 19/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 17/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130002 | 0.88 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL21129808 | 0.85 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL21130000 | 0.78 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL21130289 | 0.77 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL21130075 | 0.76 | MKNK2 (0.33) | PRMT5WDR77MKNK2 | |
| SCHEMBL23476362 | 0.76 | — | — | |
| SCHEMBL21130158 | 0.72 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL21130283 | 0.72 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL21130161 | 0.72 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL21130285 | 0.72 | PRMT5 (0.32) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980417-B1 | PRMT5 INHIBITORS | LUPIN LTD (IN) | 2023-09-27 | — | — | EP | disclosed |
| WO-2020250123-A1 | PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2020-12-17 | — | — | WO | disclosed |
| WO-2019116302-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2019-06-20 | — | — | WO | disclosed |