Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130002 | 0.84 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL21130158 | 0.82 | PRMT5 (0.39) | PRMT5WDR77 | |
| SCHEMBL21130161 | 0.81 | PRMT5 (0.43) | PRMT5WDR77 | |
| SCHEMBL21130285 | 0.81 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL21130021 | 0.78 | SIGMAR1 (0.39) | PRMT5 | |
| SCHEMBL21130291 | 0.73 | MKNK2 (0.33) | PRMT5WDR77 | |
| SCHEMBL21130176 | 0.72 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL23476391 | 0.71 | PRMT5 (0.31) | PRMT5WDR77 | |
| SCHEMBL21129809 | 0.70 | — | — | |
| SCHEMBL21129808 | 0.70 | PRMT5 (0.37) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724190-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LTD (IN) | 2022-07-06 | — | — | EP | disclosed |
| WO-2019116302-A1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | LUPIN LIMITED (IN) | 2019-06-20 | — | — | WO | disclosed |