Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.51 |
| ▸ | PFKFB3 | Q16875 | 5/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.38 |
| ▸ | SMAD2 | Q15796 | 1/20 | 0.38 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130539 | 0.90 | PDCD1 (0.51) | PDCD1CD274S1PR1S1PR3FFAR1 | |
| SCHEMBL21130597 | 0.78 | PDCD1 (0.57) | PDCD1CD274S1PR1S1PR3TGFBR1 | |
| SCHEMBL23480164 | 0.76 | DYRK1A (0.57) | PFKFB3DYRK1AMAPK14APPRIPK1 | |
| SCHEMBL21130479 | 0.75 | NPC1 (0.53) | PDCD1CD274DYRK1AS1PR1S1PR3 | |
| SCHEMBL27523310 | 0.75 | DYRK1A (0.49) | PFKFB3DYRK1AMAPK14APPRIPK1 | |
| SCHEMBL13491577 | 0.74 | CYP3A4 (0.47) | KDM4ENPC1RAB9AHKDC1TDP1 | |
| SCHEMBL28088760 | 0.74 | DYRK1A (0.51) | PFKFB3DYRK1AMAPK14FFAR1APP | |
| SCHEMBL21130426 | 0.74 | CD274 (0.52) | PDCD1CD274DYRK1AS1PR1S1PR3 | |
| SCHEMBL27558185 | 0.73 | QPCT (0.51) | PFKFB3DYRK1AMAPK14FFAR1APP | |
| SCHEMBL21130421 | 0.72 | PDCD1 (0.53) | PDCD1CD274MAPK14S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689640-B | Compounds useful as immunomodulators | 百时美施贵宝公司 | 2022-01-04 | — | — | CN | disclosed |
| EP-3481815-B1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-29 | — | — | EP | disclosed |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | CD74, CD2, HAVCR2 | PDCD1 46/4885CD274 30/4885PFKFB3 2972/4885 |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | CD74, CD2, HAVCR2 | PDCD1 46/4885CD274 30/4885PFKFB3 2972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.