Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 5/20 | 0.57 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130479 | 0.85 | NPC1 (0.53) | PDCD1CD274TGFBR1S1PR1S1PR3 | |
| SCHEMBL21130421 | 0.85 | PDCD1 (0.53) | PDCD1CD274TGFBR1S1PR1S1PR3 | |
| SCHEMBL21130539 | 0.78 | PDCD1 (0.51) | PDCD1CD274TGFBR1S1PR1S1PR3 | |
| SCHEMBL21130370 | 0.78 | PDCD1 (0.51) | PDCD1CD274TGFBR1S1PR1S1PR3 | |
| SCHEMBL21130371 | 0.78 | CD274 (0.52) | PDCD1CD274S1PR1S1PR3 | |
| SCHEMBL21130426 | 0.78 | CD274 (0.52) | PDCD1CD274TGFBR1S1PR1S1PR3 | |
| SCHEMBL28134708 | 0.77 | TGFBR1 (0.51) | TGFBR1S1PR1ALOX5APFEN1 | |
| SCHEMBL18367730 | 0.76 | CD274 (0.70) | PDCD1CD274S1PR1S1PR3EPHX1 | |
| SCHEMBL358303 | 0.73 | CD274 (1.00) | PDCD1CD274EPHX1 | |
| SCHEMBL29558512 | 0.73 | CD274 (1.00) | PDCD1CD274EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689640-B | Compounds useful as immunomodulators | 百时美施贵宝公司 | 2022-01-04 | — | — | CN | disclosed |
| EP-3481815-B1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-29 | — | — | EP | disclosed |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-20 | — | — | US | disclosed |
| CN-109689640-A | It can be used as the compound of immunomodulator | 百时美施贵宝公司 | 2019-04-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | CD74, CD2, HAVCR2 | PDCD1 46/4885CD274 30/4885TGFBR1 1392/4885 |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | CD74, CD2, HAVCR2 | PDCD1 46/4885CD274 30/4885TGFBR1 1392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.