Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.53 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.52 |
| ▸ | TDO2 | P48775 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | CCNC | P24863 | 4/20 | 0.44 |
| ▸ | CDK8 | P49336 | 4/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21130586 | 0.95 | PDCD1 (0.53) | PDCD1CD274CYP11B1CYP11B2TDO2 | |
| SCHEMBL18367730 | 0.79 | CD274 (0.70) | PDCD1CD274CCNCCDK8PIK3CD | |
| SCHEMBL30091380 | 0.78 | PDCD1 (0.69) | PDCD1CD274CYP11B1CYP11B2 | |
| SCHEMBL11074941 | 0.78 | PDCD1 (0.69) | PDCD1CD274CYP11B1CYP11B2 | |
| SCHEMBL21130421 | 0.76 | PDCD1 (0.53) | PDCD1CD274CCNCCDK8S1PR1 | |
| SCHEMBL21130479 | 0.76 | NPC1 (0.53) | PDCD1CD274CCNCCDK8AR | |
| SCHEMBL21130597 | 0.73 | PDCD1 (0.57) | PDCD1CD274S1PR1S1PR3 | |
| SCHEMBL15730179 | 0.73 | ABL1 (0.51) | CYP11B1CYP11B2TDO2ABL1PIK3CD | |
| SCHEMBL21130375 | 0.72 | PDCD1 (0.59) | PDCD1CD274ARS1PR1S1PR3 | |
| SCHEMBL20539304 | 0.71 | CD274 (0.58) | PDCD1CD274CYP11B1CYP11B2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689640-B | Compounds useful as immunomodulators | 百时美施贵宝公司 | 2022-01-04 | — | — | CN | disclosed |
| EP-3481815-B1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2021-09-29 | — | — | EP | disclosed |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2020-03-17 | — | — | US | disclosed |
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185450-A1 | 1,3-DIHYDROXY-PHENYL DERIVATIVES USEFUL AS IMMUNOMODULATORS | CD74, CD2, HAVCR2 | PDCD1 46/4885CD274 30/4885CYP11B1 336/4885 |
| US-10590105-B2 | 1,3-dihydroxy-phenyl derivatives useful as immunomodulators | CD74, CD2, HAVCR2 | PDCD1 46/4885CD274 30/4885CYP11B1 336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.