Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24972126 | 1.00 | PAOX (0.50) | PAOXMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL2801261 | 1.00 | PAOX (0.50) | PAOXMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL18127638 | 1.00 | PAOX (0.50) | PAOXMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL9987483 | 1.00 | PAOX (0.50) | PAOXMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL11963633 | 1.00 | PAOX (0.50) | PAOXMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL8056741 | 0.98 | PAOX (0.52) | PAOXMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL5155263 | 0.89 | MEN1 (0.56) | PAOXMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL19309079 | 0.89 | MEN1 (0.56) | PAOXMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL13449603 | 0.88 | MEN1 (0.47) | PAOXMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL5157716 | 0.87 | MAPK1 (0.55) | PAOXMEN1KMT2AMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118851-A1 | SMALL MOLECULE DEGRADERS THAT RECRUIT DCAFT15 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-06-20 | — | — | WO | disclosed |