Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16699032 | 0.87 | ADORA3 (0.37) | PDE4DPLATADORA3PARP1ALDH1A1 | |
| SCHEMBL18740105 | 0.82 | PDE4D (0.44) | PDE4DPLATALDH1A1MAPK1CYP1A2 | |
| SCHEMBL9940798 | 0.81 | PARP1 (0.38) | PARP1ALDH1A1MAPK1CYP1A2TSHR | |
| SCHEMBL26134476 | 0.79 | PARP1 (0.37) | ADORA3PARP1ALDH1A1CYP1A2TSHR | |
| SCHEMBL20748902 | 0.79 | PDE4D (0.39) | PDE4DPLATALDH1A1MAPK1HTT | |
| SCHEMBL9938811 | 0.79 | KDM5B (0.39) | PARP1ALDH1A1TSHRKDM4EJMJD6 | |
| SCHEMBL9977655 | 0.79 | PARP1 (0.37) | PARP1ALDH1A1TSHRKDM4EJMJD6 | |
| SCHEMBL26135724 | 0.79 | MAPT (0.37) | PARP1ALDH1A1MAPK1TSHRKDM4E | |
| SCHEMBL26134848 | 0.77 | PARP1 (0.36) | PARP1ALDH1A1TSHRKDM4EJMJD6 | |
| SCHEMBL20748971 | 0.76 | PLAT (0.39) | PDE4DPLATALDH1A1MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068785-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-26 | — | — | EP | disclosed |