Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709027 | 0.85 | NR1H2 (0.38) | BTKGPR119NR1H2ADORA1NAMPT | |
| SCHEMBL16709108 | 0.85 | BTK (0.34) | BTKGPR119NR1H2ADORA1NAMPT | |
| SCHEMBL30622794 | 0.80 | NR1H2 (0.35) | GPR119SMARCA2SMARCA4PBRM1NR1H2 | |
| SCHEMBL16711291 | 0.77 | CSNK1E (0.43) | CSNK1DCSNK1E | |
| SCHEMBL16709041 | 0.77 | RIPK2 (0.50) | BTKCSNK1DCSNK1E | |
| SCHEMBL16711379 | 0.77 | MAP4K4 (0.36) | BTKGPR119NR1H2 | |
| SCHEMBL16709072 | 0.76 | CSNK1E (0.62) | CSNK1DCSNK1E | |
| SCHEMBL16709021 | 0.76 | CSNK1E (0.50) | BTKCSNK1DCSNK1E | |
| SCHEMBL16699786 | 0.75 | NR1H2 (0.39) | GPR119NR1H2ADORA1NAMPT | |
| SCHEMBL17936871 | 0.75 | GPR119 (0.38) | GPR119NR1H2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068785-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-26 | — | — | EP | disclosed |