⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2150032 | 0.84 | IDO1 (0.36) | — | |
| SCHEMBL7490282 | 0.72 | GAA (0.32) | — | |
| Hydrochloric Acid SCHEMBL11065005 | 0.70 | GAA (0.32) | — | |
| SCHEMBL2150570 | 0.68 | — | — | |
| SCHEMBL1966927 | 0.68 | CHRNB2 (0.41) | — | |
| SCHEMBL16037386 | 0.68 | — | — | |
| SCHEMBL15326873 | 0.68 | IDO1 (0.41) | — | |
| SCHEMBL6847268 | 0.67 | — | — | |
| SCHEMBL31050976 | 0.67 | MAPT (0.59) | — | |
| SCHEMBL25434056 | 0.65 | CHRNB2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524465-B2 | Agonists of bitter taste receptors and uses thereof | DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM-REHBRUECKE (DE) | 2013-09-03 | — | — | US | disclosed |
| US-20120309703-A1 | AGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM-REHBRUECKE (DE) | 2012-12-06 | — | — | US | disclosed |
| US-8309314-B2 | Agonists of bitter taste receptors and uses thereof | DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM-REHBRUECKE (DE) | 2012-11-13 | — | — | US | disclosed |
| US-8158442-B2 | Antagonists of bitter taste receptors and uses thereof | Deutsches Institut Fuer Ernaehrungsforschung Potsdam-Rehbruecke-Stiftung Des Oefentlichen Rechts (DE) | 2012-04-17 | — | — | US | disclosed |
| US-20100130498-A1 | AGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSHES INSTITUT FUR ERNAHRUNGSFORSCHUNG POTSDAM- REHBRUCKE (DE) | 2010-05-27 | — | — | US | disclosed |
| US-20100113548-A1 | ANTAGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INSTITUT FUR ERNAHRUNGSFORSCHUNG POTSDAM-REHBRUCKE (DE) | 2010-05-06 | — | — | US | disclosed |
| EP-2137530-A2 | ANTAGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke Stiftung des Öffentlichen Rechts (DE) | 2009-12-30 | — | — | EP | disclosed |
| EP-2132564-A2 | AGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke Stiftung des Öffentlichen Rechts (DE) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008128730-A2 | ANTAGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INSTITUT FÜR ERNÄHRUNGSFORSCHUNG POTSDAM-REHBRÜCKE STIFTUNG DES ÖFFENTLICHEN RECHTS (DE) | 2008-10-30 | — | — | WO | disclosed |
| EP-1983342-A1 | Antogonists of bitter taste receptors and uses thereof | Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand (DE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2008119527-A2 | AGONISTS OF BITTER TASTE RECEPTORS AND USES THEREOF | DEUTSCHES INSTITUT FÜR ERNÄHRUNGSFORSCHUNG POSTDAM-REHBRÜCKE STIFTUNG DES ÖFFENTLICHEN RECHTS (DE) | 2008-10-09 | — | — | WO | disclosed |
| US-6770639-B2 | CELL PROLIFERATIVE; AUTOIMMUNE DISEASES; ANTIALLERGENS; ANTIINFLAMMATORY AGENTS; ANTICANCER AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-08-03 | — | — | US | disclosed |
| US-6506769-B2 | Pyridine -imidazole, -thiazole or -oxazole derivatives; treating autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2003-01-14 | — | — | US | disclosed |
| US-20020016460-A1 | Heterocyclic compounds useful as inhibitors of tyrosine kinases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-02-07 | — | — | US | disclosed |