Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28149475 | 0.88 | HDAC6 (0.78) | HDAC6HDAC1HDAC2CA12CA1 | |
| SCHEMBL28142485 | 0.88 | HDAC6 (0.78) | HDAC6HDAC1HDAC2CA12CA1 | |
| SCHEMBL28147367 | 0.87 | HDAC6 (0.62) | HDAC6HDAC1HDAC2CA12CA1 | |
| SCHEMBL15101317 | 0.84 | HDAC1 (0.56) | HDAC6HDAC1HDAC2CA12CA1 | |
| SCHEMBL21311906 | 0.83 | TP53 (0.72) | HDAC6HDAC1HDAC2TP53CA12 | |
| SCHEMBL15093074 | 0.83 | HDAC6 (0.59) | HDAC6HDAC1HDAC2TP53CA12 | |
| SCHEMBL17277182 | 0.82 | HDAC6 (0.61) | HDAC6HDAC1HDAC2CA12CA1 | |
| SCHEMBL28286802 | 0.82 | HDAC6 (0.97) | HDAC6HDAC1HDAC2CA12CA1 | |
| SCHEMBL17277184 | 0.81 | HDAC6 (0.63) | HDAC6HDAC1HDAC2CA12CA1 | |
| SCHEMBL15101642 | 0.81 | HDAC6 (0.59) | HDAC6HDAC1HDAC2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552176-B2 | Glycosylated chlorambucil analogs and uses thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120094946-A1 | GLYCOSYLATED CHLORAMBUCIL ANALOGS AND USES THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094946-A1 | GLYCOSYLATED CHLORAMBUCIL ANALOGS AND USES THEREOF | CD22, UGGT1, UGCG | HDAC6 289/4885HDAC1 784/4885HDAC2 771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.