Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21136753 | 0.83 | KRAS (0.56) | KRASCREBBP | |
| SCHEMBL21099636 | 0.81 | KRAS (0.47) | KRAS | |
| SCHEMBL21136700 | 0.81 | KRAS (0.59) | KRAS | |
| SCHEMBL21050656 | 0.75 | KRAS (1.00) | KRAS | |
| SCHEMBL21136857 | 0.75 | KRAS (1.00) | KRAS | |
| SCHEMBL21050664 | 0.75 | KRAS (1.00) | KRAS | |
| SCHEMBL21050847 | 0.74 | KRAS (0.69) | KRAS | |
| SCHEMBL21137311 | 0.74 | KRAS (0.43) | KRAS | |
| SCHEMBL21050884 | 0.71 | KRAS (0.85) | KRAS | |
| SCHEMBL21050813 | 0.71 | KRAS (0.85) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |