Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 12/20 | 0.51 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21137044 | 0.88 | KRAS (0.65) | KRASEGFR | |
| SCHEMBL21137060 | 0.81 | SUV39H2 (0.46) | SUV39H2HDAC1MAP4K4EGFRSRC | |
| SCHEMBL21136871 | 0.81 | KRAS (0.49) | KRAS | |
| SCHEMBL21136897 | 0.80 | SUV39H2 (0.42) | KRASSUV39H2HDAC1MAP4K4EGFR | |
| SCHEMBL21099321 | 0.80 | KRAS (0.77) | KRAS | |
| SCHEMBL21137067 | 0.77 | KRAS (0.51) | KRASEGFR | |
| SCHEMBL18128394 | 0.75 | KRAS (0.60) | KRASSUV39H2HDAC1MAP4K4EGFR | |
| SCHEMBL21099596 | 0.74 | KRAS (0.76) | KRAS | |
| SCHEMBL21099362 | 0.74 | KRAS (0.76) | KRAS | |
| SCHEMBL21137485 | 0.74 | KRAS (0.41) | KRASSUV39H2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |