Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 6/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099327 | 0.80 | KRAS (0.64) | KRAS | |
| SCHEMBL21137067 | 0.79 | KRAS (0.51) | KRASEGFR | |
| SCHEMBL21137062 | 0.77 | KRAS (0.65) | KRASEGFR | |
| SCHEMBL21137320 | 0.77 | KRAS (0.43) | KRASSUV39H2MAP4K1ALKEGFR | |
| SCHEMBL21136787 | 0.77 | KRAS (0.44) | KRASSUV39H2MAP4K1ALKPGK1 | |
| SCHEMBL20448825 | 0.76 | SUV39H2 (0.44) | SUV39H2MAP4K1ALK | |
| SCHEMBL16637000 | 0.74 | KRAS (0.44) | KRASMAP4K1ALKEGFR | |
| SCHEMBL21136727 | 0.74 | KRAS (0.51) | KRASSUV39H2EGFR | |
| SCHEMBL16647167 | 0.73 | LRRK2 (0.45) | KRASTLR9TLR7SUV39H2MAP4K1 | |
| SCHEMBL17030859 | 0.73 | PDGFRB (0.44) | TLR9TLR7SUV39H2MAP4K1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |