Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21136786 | 0.92 | CCNE2 (0.32) | CCNE2CCNE1CDK2 | |
| SCHEMBL21136881 | 0.85 | CCNE2 (0.33) | CCNE2CCNE1CDK2 | |
| SCHEMBL21136745 | 0.84 | ACKR3 (0.31) | CCNE2CCNE1CDK2 | |
| SCHEMBL21137483 | 0.74 | KRAS (0.49) | KRAS | |
| SCHEMBL21099209 | 0.74 | KRAS (0.40) | KRAS | |
| SCHEMBL21099612 | 0.71 | KRAS (0.50) | KRAS | |
| SCHEMBL21050747 | 0.67 | KRAS (0.43) | KRAS | |
| SCHEMBL32677269 | 0.67 | PLA2G10 (0.32) | CCNE2CCNE1CDK2 | |
| SCHEMBL21136722 | 0.66 | MAP4K4 (0.42) | — | |
| SCHEMBL29998951 | 0.66 | PIK3CD (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |