Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21136775 | 0.85 | MET (0.47) | MAPK8RETPOLBCKS1BSKP1 | |
| SCHEMBL21050917 | 0.84 | SMARCA2 (0.38) | SMARCA2SMARCA4PBRM1POLBMEN1 | |
| SCHEMBL21137364 | 0.82 | PGK1 (0.37) | MAP4K4MAPK8POLBCKS1BSKP1 | |
| SCHEMBL21099211 | 0.82 | SMARCA2 (0.37) | SMARCA2SMARCA4PBRM1POLBGPR119 | |
| SCHEMBL16637964 | 0.81 | KIT (0.52) | MAP4K4KITBACE1 | |
| SCHEMBL29611800 | 0.81 | KIT (0.52) | MAP4K4KITBACE1 | |
| SCHEMBL13156635 | 0.80 | GBA1 (0.53) | MAP4K4SMARCA2SMARCA4PBRM1KIT | |
| SCHEMBL16637332 | 0.79 | CNR1 (0.44) | SMARCA2SMARCA4PBRM1MAPK8KIT | |
| SCHEMBL29765713 | 0.79 | CNR1 (0.44) | SMARCA2SMARCA4PBRM1MAPK8KIT | |
| SCHEMBL30897155 | 0.78 | BACE1 (0.47) | MAP4K4MAPK8RETKITPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |