Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | PGK1 | P00558 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 10/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16637342 | 0.80 | KIT (0.52) | TLR9 | |
| SCHEMBL21137523 | 0.79 | SUV39H2 (0.44) | ALKPGK1TLR9SUV39H2GPR119 | |
| SCHEMBL21137076 | 0.79 | SUV39H2 (0.44) | ALKPGK1TLR9SUV39H2GPR119 | |
| SCHEMBL21136722 | 0.76 | MAP4K4 (0.42) | SUV39H2GPR119RET | |
| SCHEMBL21137060 | 0.74 | SUV39H2 (0.46) | ALKPGK1TLR9SUV39H2GPR119 | |
| SCHEMBL23727334 | 0.74 | MAPT (0.52) | TLR9GPR119TLR7 | |
| SCHEMBL30080182 | 0.74 | MAPT (0.52) | TLR9GPR119TLR7 | |
| SCHEMBL30080180 | 0.74 | MAPT (0.52) | TLR9GPR119TLR7 | |
| SCHEMBL21050889 | 0.73 | KRAS (0.51) | GPR119 | |
| SCHEMBL21137320 | 0.73 | KRAS (0.43) | ALKSUV39H2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |