SCHEMBL21137544

SCHEMBL21137544

CC(C)(C)OC(=O)CCCn1ccc2c(Cl)ncnc21

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 2/20 0.38
FGFR4 P22455 2/20 0.38
SLC22A12 Q96S37 1/20 0.38
ABL1 P00519 2/20 0.37
BCR P11274 2/20 0.37
TNF P01375 3/20 0.34
NOTUM Q6P988 2/20 0.34
DUT P33316 1/20 0.33
ACACB O00763 1/20 0.33
HDAC6 Q9UBN7 2/20 0.32
FPR2 P25090 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4014331 0.85 HDAC6 (0.41) FGFR1FGFR4SLC22A12NOTUMHDAC6
SCHEMBL21137545 0.81 NOTUM (0.43) FGFR1FGFR4SLC22A12ABL1BCR
SCHEMBL24669199 0.81 DRD2 (0.43) FGFR1FGFR4SLC22A12
SCHEMBL16363382 0.79 FGFR1 (0.43) FGFR1FGFR4SLC22A12ABL1BCR
SCHEMBL28112933 0.78 NOTUM (0.43) FGFR1FGFR4SLC22A12ABL1BCR
SCHEMBL3401964 0.77 TNF (0.45) FGFR1FGFR4SLC22A12ABL1BCR
SCHEMBL31330492 0.76 SLC22A12 (0.41) FGFR1FGFR4SLC22A12ABL1BCR
SCHEMBL27849552 0.75 KDM4E (0.44) FGFR1FGFR4SLC22A12ABL1BCR
SCHEMBL1897615 0.74 SLC22A12 (0.41) FGFR1FGFR4SLC22A12ABL1BCR
SCHEMBL31720885 0.74 SLC22A12 (0.41) FGFR1FGFR4SLC22A12ABL1BCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11970506-B2 Bioactive molecule conjugate, preparation method and use thereof SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2024-04-30 US disclosed
US-20230357259-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2023-11-09 US disclosed
US-20230357259-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2023-11-09 US disclosed
US-20210101906-A2 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2021-04-08 US disclosed
US-20200347075-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2020-11-05 US disclosed
US-20200347075-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) 2020-11-05 US disclosed
EP-3725798-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2020-10-21 EP disclosed
EP-3725798-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2020-10-21 EP disclosed
WO-2019114666-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2019-06-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230357259-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF DOCK11, PAICS, RHOA FGFR1 2055/4885FGFR4 1994/4885SLC22A12 1445/4885
US-11970506-B2 Bioactive molecule conjugate, preparation method and use thereof PIGO, RHOA, GUSB FGFR1 424/4885FGFR4 1195/4885SLC22A12 3508/4885
US-20200347075-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF DOCK11, PAICS, RHOA FGFR1 2055/4885FGFR4 1994/4885SLC22A12 1445/4885
US-20210101906-A2 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF DOCK11, PAICS, RHOA FGFR1 2055/4885FGFR4 1994/4885SLC22A12 1445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.