Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | HRH2 | P25021 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18181915 | 0.88 | MEN1 (0.51) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL2349988 | 0.83 | CYP1A2 (0.59) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL13034785 | 0.83 | CYP1A2 (0.52) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2344160 | 0.82 | CYP1A2 (0.58) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL20576715 | 0.81 | HRH3 (0.66) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL20576716 | 0.81 | HRH3 (0.66) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL19171159 | 0.80 | CYP1A2 (0.52) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL17303778 | 0.80 | CYP1A2 (0.52) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL18466271 | 0.80 | HRH4 (0.53) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL29501437 | 0.76 | CYP1A2 (0.49) | CYP1A2CYP2C19CYP3A4HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3498701-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2019-06-19 | — | — | EP | disclosed |