Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.67 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4213804 | 1.00 | KMO (0.67) | KMOJAK3DRD2DRD3PRMT5 | |
| SCHEMBL19465286 | 0.92 | KMO (0.69) | KMODRD2DRD3 | |
| SCHEMBL1633310 | 0.90 | KMO (0.71) | KMOHTR2C | |
| Hydrochloric Acid SCHEMBL6709116 | 0.89 | KMO (0.69) | KMOHTR2C | |
| SCHEMBL13406411 | 0.88 | KMO (0.72) | KMODRD2DRD3HTR2C | |
| SCHEMBL13406410 | 0.88 | KMO (0.72) | KMODRD2DRD3HTR2C | |
| SCHEMBL30344892 | 0.86 | PARP1 (0.53) | KMOJAK3DRD2DRD3PRMT5 | |
| Hydrochloric Acid SCHEMBL28155975 | 0.85 | PARP1 (0.51) | KMOJAK3DRD2DRD3PRMT5 | |
| Hydrochloric Acid SCHEMBL28155974 | 0.85 | PARP1 (0.51) | KMOJAK3DRD2DRD3PRMT5 | |
| SCHEMBL347728 | 0.82 | HTR2C (0.48) | JAK3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |
| EP-3498701-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2019-06-19 | — | — | EP | disclosed |