Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.38 |
| ▸ | KDR | P35968 | 7/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2114657 | 0.93 | CHEK1 (0.41) | CHEK1PDGFRBFGFR1KDREGFR | |
| SCHEMBL2114212 | 0.89 | KDR (0.44) | CHEK1PDGFRBFGFR1KDREGFR | |
| SCHEMBL2114981 | 0.84 | CHEK1 (0.40) | CHEK1PDGFRBFGFR1KDREGFR | |
| SCHEMBL2114496 | 0.83 | LRRK2 (0.42) | CHEK1PDGFRBFGFR1KDREGFR | |
| SCHEMBL2116233 | 0.83 | FLT3 (0.41) | CHEK1PDGFRBFGFR1KDREGFR | |
| SCHEMBL2113949 | 0.81 | KDR (0.41) | CHEK1PDGFRBFGFR1KDREGFR | |
| SCHEMBL2118573 | 0.79 | CHEK1 (0.39) | CHEK1PDGFRBFGFR1KDREGFR | |
| SCHEMBL1673441 | 0.78 | ALK (0.52) | CHEK1PDGFRBFGFR1KDREGFR | |
| SCHEMBL2117957 | 0.78 | MEN1 (0.46) | PDGFRBFGFR1KDREGFRSRC | |
| SCHEMBL395533 | 0.78 | FLT3 (0.48) | PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | NEKTAR THERAPEUTICS (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094998-A1 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates | PTK2B, ERBB2, FRK | CHEK1 716/4885PDGFRB 555/4885FGFR1 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.